Chemokine Receptor CCR2 Is Not Essential for the Development of Experimental Cerebral Malaria

AUTOR(ES)

Belnoue, Elodie

FONTE

American Society for Microbiology

RESUMO

Infection with Plasmodium berghei ANKA induces cerebral malaria in susceptible mice. Brain-sequestered CD8+ T cells are responsible for this pathology. We have evaluated the role of CCR2, a chemokine receptor expressed on CD8+ T cells. Infected CCR2-deficient mice were as susceptible to cerebral malaria as wild-type mice were, and CD8+ T-cell migration to the brain was not abolished.

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