Chemokines and their role in airway hyper-reactivity

AUTOR(ES)

Blease, Kate

FONTE

BioMed Central

RESUMO

Airway hyper-reactivity is a characteristic feature of many inflammatory lung diseases and is defined as an exaggerated degree of airway narrowing. Chemokines and their receptors are involved in several pathological processes that are believed to contribute to airway hyper-responsiveness, including recruitment and activation of inflammatory cells, collagen deposition and airway wall remodeling. These proteins are therefore thought to represent important therapeutic targets in the treatment of airway hyper-responsiveness. This review highlights the processes thought to be involved in airway hyper-responsiveness in allergic asthma, and the role of chemokines in these processes. Overall, the application of chemokines to the prevention or treatment of airway hyper-reactivity has tremendous potential.

Documentos Relacionados

• Hyper-reactivity of Rabbits Sensitized with Bartonella bacilliformis
• The "healthy passive smoker": relationship between bronchial hyper-reactivity in school children and maternal smoking.
• Sympathomimetics and airway hyperreactivity.
• Airway epithelial cell expression of interleukin-6 in transgenic mice. Uncoupling of airway inflammation and bronchial hyperreactivity.
• Simvastatin Inhibits Airway Hyperreactivity: Implications for the Mevalonate Pathway and Beyond