Chemotherapy of an Experimental Fusobacterium (Sphaerophorus) necrophorum Infection in Mice
AUTOR(ES)
Wilkins, Tracy D.
RESUMO
An experimental animal model for testing antibiotics in vivo against Fusobacterium (Sphaerophorus) necrophorum has been developed. It incorporates the subcutaneous injection of the bacteria into mice followed by intraperitoneal administration of the antibiotic at 24, 48, 72, and 96 h. Mean effective dose values are based on the number of survivors 21 days after challenge. Tetracycline was the most effective drug tested, with a mean effective dose of 5.0 mg/kg, compared with mean effective dose values of 11.1 for clindamycin, 11.8 for penicillin-G, and 52.9 for lincomycin.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=429030Documentos Relacionados
- Chemotherapy of an Experimental Bacteroides fragilis Infection in Mice
- Evaluation of experimentally induced Fusobacterium necrophorum infections in mice.
- Comparison of extracellular enzymes of Fusobacterium necrophorum subsp. necrophorum and Fusobacterium necrophorum subsp. funduliforme.
- Comparison of Cefoxitin and Cephalothin Therapy of a Mixed Bacteroides fragilis and Fusobacterium necrophorum Infection in Mice
- Meningitis due to Fusobacterium necrophorum in an adult
