Chlamydia-Infected Cells Continue To Undergo Mitosis and Resist Induction of Apoptosis

AUTOR(ES)

Greene, Whitney

FONTE

American Society for Microbiology

RESUMO

Both anti- and proapoptotic activities have been reported to occur during chlamydial infection. To reconcile the apparent controversy, we compared host cell apoptotic responses to infection with 17 different chlamydial serovars and strains. None of the serovars caused any biologically significant apoptosis in the infected host cells. Host cells in chlamydia-infected cultures can continue to undergo DNA synthesis and mitosis. Chlamydia-infected cells are resistant to apoptosis induction, although the extent of the antiapoptotic ability varied between serovars. These observations have demonstrated that an anti- but not proapoptotic activity is the prevailing event in chlamydia-infected cultures.

Documentos Relacionados

• Glycogen Metabolism in Chlamydia-Infected HeLa-Cells
• Characterization of gamma interferon-mediated cytotoxicity to chlamydia-infected fibroblasts.
• Deoxyribonucleic acid synthesis, cell cycle progression, and division of Chlamydia-infected HeLa 229 cells.
• Long-term effects of gamma interferon on chlamydia-infected host cells: microbicidal activity follows microbistasis.
• Expression of Mucosal Homing Receptor α4β7 Is Associated with Enhanced Migration to the Chlamydia-Infected Murine Genital Mucosa In Vivo