Chloramphenicol acetyltransferase may confer resistance to fusidic acid by sequestering the drug.
AUTOR(ES)
Proctor, G N
RESUMO
Enterobacterial chloramphenicol acetyltransferase bound fusidic acid with high affinity, but did not acetylate the drug at an experimentally detectable rate. The enzyme may therefore confer resistance to fusidic acid by sequestering the drug and thereby preventing the drug from binding to translational elongation factor G.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=217776Documentos Relacionados
- Chloramphenicol acetyltransferase should not provide methanogens with resistance to chloramphenicol.
- Resistance to chloramphenicol in Proteus mirabilis by expression of a chromosomal gene for chloramphenicol acetyltransferase.
- Relationship Between Chloramphenicol Acetyltransferase Activity and the Number of Resistance Genes
- Mechanism of Chloramphenicol Resistance in Staphylococci: Characterization and Hybridization of Variants of Chloramphenicol Acetyltransferase
- Use of commercially available rapid chloramphenicol acetyltransferase test to detect resistance in Salmonella species.
