Chromatin remodeling enzymes: taming the machines: Third in review series on chromatin dynamics
AUTOR(ES)
Peterson, Craig L.
FONTE
Oxford University Press
RESUMO
Members of the ATP-dependent family of chromatin remodeling enzymes play key roles in the regulation of transcription, development, DNA repair and cell cycle. Each of these enzymes are multi-subunit assemblies that hydrolyze thousands of molecules of ATP in order to change nucleosome positions, disrupt DNA–histone interactions and perhaps destabilize chromatin folding. Here I review recent studies that suggest these potent machines can be ‘tamed’ by one of several mechanisms: targeting their activity to localized regions, blocking their chromatin binding activity or inhibiting their remodeling activity.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1084063Documentos Relacionados
- Crystalline molecular machines: Encoding supramolecular dynamics into molecular structure
- Histone acetylation: a switch between repressive and permissive chromatin: Second in review series on chromatin dynamics
- When repair meets chromatin: First in series on chromatin dynamics
- Designed transcription factors as structural, functional and therapeutic probes of chromatin in vivo: Fourth in review series on chromatin dynamics
- Series on Chromatin Dynamics: Dedication to Alan Wolffe