Chromenes from leaves of Calea pinnatifida and evaluation of their leishmanicidal activity
AUTOR(ES)
Lima, Tamires C., Santos, Alan Diego C., Costa, Danielle T.M., Souza, Rafaela J., Barison, Andersson, Steindel, Mário, Biavatti, Maique W.
FONTE
Rev. bras. farmacogn.
DATA DE PUBLICAÇÃO
2015-02
RESUMO
Calea pinnatifida (R. Br.) Less., Asteraceae, is popularly known as “quebra-tudo”, “cipó-cruz” or “aruca”. This species is used in the folk medicine for the treatment of stomach pain, giardiasis and amoebiasis. The aim of this study was to isolate and identify chromenes from leaves of C. pinnatifida and evaluate their leishmanicidal activity. A fraction from leaves of C. pinnatifida was analyzed for their chemical constituents, resulting in the isolation and characterization of four known chromenes: 6-acetyl-7-hydroxy-2,2-dimethylchromene (1), 6-acetyl-7-methoxy-2,2-dimethylchromene (2), 6-(1-hydroxyethyl)-7-methoxy-2,2-dimethylchromene (3) and 6-(1-ethoxyethyl)-7-methoxy-2,2-dimethylchromene (4). Structure identification of isolated compounds involved analysis of spectral data of 1D and 2D-NMR. The isolated compounds are here reported for the first time in C. pinnatifida, and the chromenes 1 and 3 show a moderate leishmanicidal activity.
Documentos Relacionados
- A New Furanoheliangolide Sesquiterpene Lactone from Calea pinnatifida (R. Br.) Less. (Asteraceae) and Evaluation of Its Trypanocidal and Leishmanicidal Activities
- Anticancer activity of Calea pinnatifida banks leaves crude extract and fractions
- Chemical constituents from Sidastrum paniculatum and evaluation of their leishmanicidal activity
- Isolation and characterization of sesquiterpene lactones from Calea uniflora Less. and their leishmanicidal and trypanocidal activities
- Chemical constituents and leishmanicidal activity from leaves of Kielmeyera variabilis