Chromosomal assignment of the mouse kappa light chain genes.
AUTOR(ES)
Swan, D
RESUMO
Mouse-hamster somatic cell hybrids containing a variable number of mouse chromosomes have been used in experiments to determine which mouse chromosome carries the immunoglobulin kappa light chain genes. It has been shown by nucleic acid hybridization that the kappa constant gene and the genes for at least one variable region subgroup are on mouse chromosome 6. This somatic cell genetic mapping procedure appears to be general and can be applied to any expressed or silent gene for which an appropriate nucleic acid probe exists.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=383683Documentos Relacionados
- DNase I-hypersensitive sites in the chromatin of immunoglobulin kappa light chain genes.
- Organization of four mouse lambda light chain immunoglobulin genes.
- DNA sequences of the joining regions of mouse lambda light chain immunoglobulin genes.
- Two rearranged immunoglobulin kappa light chain genes in one mouse myeloma.
- Chromosomal locations of mouse immunoglobulin genes.