Chromosomal breakage in normal and fragile X subjects using low folate culture conditions.
AUTOR(ES)
Vekemans, M
RESUMO
To investigate whether the fragile X syndrome is associated with a generalised chromosomal instability, we compared the frequency and distribution of chromosomal breakage in lymphocytes grown in low folate medium from normal subjects and from patients with the syndrome. Although low folate conditions increased the rate of chromosome breakage, no difference in frequency or distribution of chromosomal breakage was found between the two groups. This suggests that the fragile X syndrome is not associated with a generalised chromosome instability expressed in folate deficient medium and assessed in terms of chromosomal breakage.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1049167Documentos Relacionados
- Linkage analysis using multiple Xq DNA polymorphisms in normal families, families with the fragile X syndrome, and other families with X linked conditions.
- Isolation of the human chromosomal band Xq28 within somatic cell hybrids by fragile X site breakage.
- Maximal biomass of Arabidopsis thaliana using a simple, low-maintenance hydroponic method and favorable environmental conditions.
- Erythroid differentiation and commitment in rat erythroleukemia cells with hypertonic culture conditions.
- Cultivation of Neisseria gonorrhoeae under low-oxygen conditions.