Chromosomal localization of human genes governing the interferon-induced antiviral state.
AUTOR(ES)
Chany, C
RESUMO
Interferon sensitivity of different normal and aneusomic human cells and of different mouse-human hybrids cells has been compared. G21 trisomic cells are more sensitive than diploid cells; whereas, on the contrary, triploid cells are normal in their human interferon sensitivity. Among other aneusomic cell lines tested, E16 trisomic cells are significantly less sensitive. These data are in favor of the hypotheses that the G21 chromosome carries genetic information for structural proteins involved in the receptor system for interferon, that there is a regulatory mechanism governing the antiviral state, and that the E16 chromosome is a possible candidate for carrying information for such a depressive regulatory mechanism. None of the chromosome abnormalities studies are involved with interferon synthesis.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=432934Documentos Relacionados
- Interferon-induced proteins in human fibroblasts and development of the antiviral state.
- Establishment and Maintenance of the Interferon-Induced Antiviral State: Studies in Enucleated Cells
- Antiviral state against influenza virus neutralized by microinjection of antibodies to interferon-induced Mx proteins.
- Sendai Virus Targets Inflammatory Responses, as Well as the Interferon-Induced Antiviral State, in a Multifaceted Manner
- PML mediates the interferon-induced antiviral state against a complex retrovirus via its association with the viral transactivator