Chromosomal localization of three endogenous retrovirus loci associated with virus production in White Leghorn chickens.

AUTOR(ES)

Tereba, A

RESUMO

Proposed mechanisms for the generation of endogenous retrovirus loci have been examined by determining the chromosomal distribution of these loci by means of in situ hybridization. Unlike the clustering on chromosome 1 of five endogenous retrovirus loci associated with the gs- chf- phenotype A. Tereba and S. M. Astrin, submitted for publication), three loci associated with endogenous retrovirus production (V+ phenotype) were located on three separate chromosomes. ev2, which codes for the prototype endogenous RAV-0 genome in line 7(2) chickens, was localized near the middle of the long arm of chromosome 2, ev7, coding for a noninfectious, inducible genome present in line 15B chickens, was located near the end of the long arm of the Z chromosome. A third V+ locus, designated ev14, was detected near the middle of chromosome 3. This arrangement of V+ loci is consistent with an integration mechanism employing randomly distributed integration sites in the chicken genome. In addition, these data provide evidence suggesting that the gs- chf- -associated loci may have been generated by a different mechanism.

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