Chromosome 11 allele loss in sporadic insulinoma.
AUTOR(ES)
Patel, P
RESUMO
DNA was extracted from tissue samples of three unrelated cases of insulinoma. Chromosome 11 allele loss was investigated using several chromosome 11 specific probes which detect restriction fragment length polymorphisms. In one case, which proved informative for many of the chromosome 11 markers, allele loss was shown on both 11p and 11q. This finding is of considerable interest as the allele loss closely corresponds to that recently reported in insulinomas occurring in the familial multiple endocrine neoplasia type 1 (MEN-1) syndrome.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=502433Documentos Relacionados
- Chromosome 11q in sporadic colorectal carcinoma: patterns of allele loss and their significance for tumorigenesis.
- Loss of allelic heterozygosity at a second locus on chromosome 11 in sporadic Wilms' tumor cells.
- Forced diuresis to reduce nephrotoxicity of streptozotocin in the treatment of advanced metastatic insulinoma.
- A case report of paroxysmal dystonic choreoathetosis due to hypoglycaemia induced by an insulinoma.
- Identification of the major polyadenylylated transcription products and the genes active in their synthesis in a rat insulinoma.