Ciliary neurotrophic factor prevents retrograde neuronal death in the adult central nervous system.
AUTOR(ES)
Clatterbuck, R E
RESUMO
The neurocytokine ciliary neurotrophic factor (CNTF) was described originally as an activity that supports the survival of neurons of the chicken ciliary ganglia in vitro. The widespread expression of CNTF and its principal binding protein, CNTF receptor alpha, in the central and peripheral nervous systems suggests a broader trophic role for this peptide. In the present study, we report that CNTF prevents axotomy-induced cell death of neurons in the anteroventral and anterodorsal thalamic nuclei of the adult rat. Using the polymerase chain reaction, we also demonstrate the presence of CNTF and CNTF receptor alpha mRNA in these same thalamic nuclei. The coincidence of CNTF and its receptor in a population of neurons responding to the factor suggests a paracrine function for CNTF. The present findings establish that CNTF has significant effects on neurons of the central nervous system in vivo and demonstrate that neurocytokines can prevent cell death in the adult central nervous system.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=46058Documentos Relacionados
- Ciliary neurotrophic factor prevents degeneration of adult rat substantia nigra dopaminergic neurons in vivo.
- Expression of the murine fibroblast growth factor 5 gene in the adult central nervous system.
- A role for ciliary neurotrophic factor as an inducer of reactive gliosis, the glial response to central nervous system injury.
- Persistent expression of helix-loop-helix factor HES-1 prevents mammalian neural differentiation in the central nervous system.
- Monoclonal antibodies distinguish antigenically discrete neuronal types in the vertebrate central nervous system.