Circulating Immune Complexes after Renal Transplantation: CORRELATION OF INCREASED 125I-C1q BINDING ACTIVITY WITH ACUTE REJECTION CHARACTERIZED BY FIBRIN DEPOSITION IN THE KIDNEY
AUTOR(ES)
Ooi, Yuet M.
RESUMO
To assess the role of circulating immune complexes in the pathogenesis of acute rejection, sera were measured for such complexes by the 125I-C1q binding assay in 45 normal subjects, 24 allografted patients undergoing acute rejection, and in 11 allografted patients in a quiescent phase. Increased C1q-binding activity (C1q-BA) was detected in 14 patients with acute rejection, 9 of whom had renal biopsies showing fibrin deposition in the vasculature together with cellular infiltrates in the tubulo-interstitial structures; renal histology was not available in the other 5 patients. The other 10 patients with acute rejection, whose biopsies showed only cellular infiltrates, and the 11 patients in a quiescent phase posttransplantation did not have increased levels of serum C1q-BA.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=372405Documentos Relacionados
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