Cleft lips and palate and obesity / Obesidade e o nascimento de bebês com fendas lábio-palatinas
AUTOR(ES)
Adriana Teixeira Rodrigues
DATA DE PUBLICAÇÃO
2006
RESUMO
Introduction The incidence of cleft lips and palate is 1 to 700 live births in the world population, it is a congenital malformation that can happens due to endogens or exogenesis factors. Objectives Association between maternal body mass index (BMI) and the risk of cleft lips or palate. Methods That is a case control study. We include 800 mothers between 18 and 35 years old without suspicious of gestational or preexisting diabetes and babies between 2,500 e 4, 000 g was born between the 37 and 42 pregnancy week without other congenital malformation that is not the studied. Some questions were asked for 400 normal childrens mothers from four health centers from Santo André (controls), and 400cleft lips or palate childrens mothers from FUNCRAF that is a health center just to treatment of this malformation, from Santo André (cases). Results Among the cases we have 148 (37.00%) mothers with BMI above 26 and among the controls it was 132 (33.00%). About alcohol and drugs use we have 82 (20.50%) women among cases and 58 (14.50%) on control group. Two hundred eleven (52.70%) malformations childrens mothers declare to have malformation parental history against 103 (25.70%) on control group. On control group we have 330 (82.50%) white , 43 (10.75%) black and 27 (6.70%) yellow, among the cases 294 (73.50%) white, 65 (16.25%) black and 40 (10.00%) yellow. Conclusions The increase of BMI is not likely to be a risk factor for clefts, the consumption of alcohol/drugs is a risk factor for this malformation; the risk is 3.6 times highest for clefts when there is malformation history; a racial association with clefts was observed, the white women presents the lowest association and the yellow presents the highest one.
ASSUNTO(S)
clefts Álcool/drogas má-formações body mass index(bmi) defeitos do tubo neural fendas alcohol/drugs malformations raça race Índice de massa corporal(imc) neural tube defects
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