Clinical evaluation of oral changes in patients seropositive for the HTLV / Avaliação clínica de alterações bucais em pacientes soropositivos para o HTLV
AUTOR(ES)
Fabiana Martins e Martins
DATA DE PUBLICAÇÃO
2008
RESUMO
HTLV-1 (human T-lymphotropic virus), the first retrovirus discovered, is associated with adult T cell leukemia/lymphoma (ATL) and tropical spastic paraparesis / HTLV associated myelopathy (TSP / HAM). Clinical studies and case reports in endemic areas showed the development of oral ALT and Sjögren`s syndrome in this patients. The aim of this study was to investigate the oral cavity of HTLV seropositive patients in São Paulo city. The present study was approved by the Institute of Infectious Diseases Emílio Ribas ethics committee. All patients answered a questionnaire designed for the study. Demographic and clinical data were recorded and then analyzed using Epi info (3.3.4 version) and SPSS Statistical Package for Social Sciences (v16.0). One hundred and thirty nine oral examinations were performed, 112 (80,5%) were HTLV-1 +, 26 were (18,7%) HTLV-2 + and one patient presented both types of HTLV. Sixty four (56,7%) were asymptomatic HTLV-1 seropositive patients, fourty nine (43,3%) patients were positive for HTLV-1 and TSP/HAM. HIV and HCV co-infection and comorbities were observed in 110 (79,1%) cases. Xerostomia (26,5%), candidosis (25,4%), oral fissured tongue (22,1%) and papillary atrophy of the tongue (12,4%) were the most prevalent oral manifestations found in these patients. Models of multivariate logistic regression confirmed the TSP / HAM as an independent risk factor for xerostomia (p = 0.02). Patients with TSP / HAM + were 3 times more likely to develop xerostomia when compared with patients without TSP / HAM (OR = 2.69, 95% CI = 1.17-6.17).
ASSUNTO(S)
htlv tsp/ham tsp/ham epidemiologia epidemiology htlv atl atl
Documentos Relacionados
- Evaluation of oral manifestations in liver transplanted pediatric patients
- Aspectos demográficos e manifestações clínicas bucais de pacientes soropositivos para o HIV/Aids
- Assessment of oral manifestations in patients with renal failure
- Avaliação da atividade fibronolitica oral em pacientes sob anticoagulação oral
- AVALIAÇÃO DE PACIENTES AMBULATORIAIS EM USO DE ANTICOAGULANTES ORAIS