Clinical Isolates of Staphylococcus aureus with Ribosomal Mutations Conferring Resistance to Macrolides
AUTOR(ES)
Prunier, Anne-Laure
FONTE
American Society for Microbiology
RESUMO
Six strains of Staphylococcus aureus isolated from cystic fibrosis patients after treatment with azithromycin were cross-resistant to azithromycin and erythromycin. None of the isolates contained erm or msr(A) genes, but they all carried either A2058G/U or A2059G mutations within the rrl genes, with a majority of the rRNA copies bearing the mutation. One strain displayed an additional mutation in the rplV gene, encoding the L22 ribosomal protein.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=127407Documentos Relacionados
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