Cloned Lines of Plasmodium berghei ANKA Differ in Their Abilities To Induce Experimental Cerebral Malaria
AUTOR(ES)
Amani, Véronique
FONTE
American Society for Microbiology
RESUMO
Infection with Plasmodium berghei ANKA is usually lethal. The parasite causes in some mouse strains a neurovascular syndrome, experimental cerebral malaria (ECM), involving immunopathological reactions. The effects on the development of ECM of the mouse genetic background have been clearly demonstrated, but nothing is known about the effects of the clonal diversity of the parasite. We showed that various cloned lines derived from a polyclonal line of P. berghei ANKA caused ECM but that the extent of ECM induction was dependent on the amount of inoculum. Subtle differences in ECM characteristics (survival time and hypothermia) were also observed. We also confirmed, using the 1.49L cloned line, that the mouse genetic background strongly affects ECM.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=108491Documentos Relacionados
- Susceptibility to Experimental Cerebral Malaria Induced by Plasmodium berghei ANKA in Inbred Mouse Strains Recently Derived from Wild Stock
- γδ T-Cell Function in Pathogenesis of Cerebral Malaria in Mice Infected with Plasmodium berghei ANKA
- Papel do fator de ativação plaquetário (PAF) na malária experimental induzida por Plasmodium berghei cepa ANKA
- Influência da pentoxifilina sobre a infecção murina por Plasmodium berghei anka em modelos susceptíveis ou não à malária cerebral
- Influência da talidomida sobre a infecção murina por Plasmodium berghei anka em modelos susceptíveis ou não à malária cerebral
