Clusters of Identical New Mutations Can Account for the ``overdispersed'' Molecular Clock

AUTOR(ES)

Huai, H.

RESUMO

Germ-cell mutations may occur during meiosis, giving rise to independent mutant gametes in a Poisson process, or before meiosis, giving rise to multiple copies of identical mutant gametes at a much higher probability than the Poisson expectation. We report that the occurrence of these early premeiotic clusters of new identical mutant alleles increases the variance-to-mean ratio of mutation rate (R(u) > 1). This leads to an expected variance-to-mean ratio (R(t)) of the molecular clock that is always greater than one and may cover the observed range of R(t) values. Hence, the molecular clock may not be over-dispersed based on this new mutational model that includes clusters. To get a better estimation of R(u) and R(t), one needs measurements of the intrageneration variation of reproductive success (N(i)/N(e(i))), population dynamics (k(i)), and the proportion of new mutations that occur in clusters (r(c)), especially those formed before germ-cell differentiation.

Documentos Relacionados

• On the Overdispersed Molecular Clock
• More on the Overdispersed Molecular Clock
• Dynamical resonance can account for seasonality of influenza epidemics
• Vagaries of the molecular clock
• The molecular clock may be an episodic clock.