Combined tretinoin and glycolic acid treatment for improvement of the mouth opening in burned patients / Efeito do tratamento combinado com tretinóina e ácido glicólico na abertura bucal de pacientes com seqüela de queimadura

AUTOR(ES)
DATA DE PUBLICAÇÃO

2003

RESUMO

Tissue repair processes evolve with alterations of the cutaneous physical properties, which are proportional, among other factors, to the original depth of the lesion. At examination, the skin is dry, dyschromic and less elastic, specially in hypertrophic scars. Post-burn skin characteristics can be improved by topical agents regularly used in pathologies like acne or photodamage. We evaluated 77 patients who had peri-oral burn sequela. The ages ranged from six to 46 years old. The tegument was classified as restored, when spontaneously healed, or skin grafted. The topical treatment consisted of tretinoin (0,01-0,05%) and glycolic acid (5-7%) for three months. Inter-incisal (D) and inter-labial (L) distances were measured at maximal mouth opening with a digital pachymeter. Both inter-incisal and inter-labial distances increased significantly in the groups treated when compared to respective controls (p£0,01). This fact was similar in both types of tegument. Inter-labial distance (L) increased significantly more than D. We suggest its use as a complementary measure to inter-incisal distance for indirect evaluation of skin elasticity in the post-burn tegument.

ASSUNTO(S)

skin/physiopathology mouth abnormalities/therapy tretinoína/uso terapêutico hidroxiácidos/uso terapêutico pele/fisiopatologia tretinoin/therapeutic use estudos de casos e controles burn units/therapy case-control studies hydroxy acids/therapeutic use queimaduras/terapia follow-up studies administração tópica anormalidades da boca/terapia cicatrix hypertrophic/therapy cicatriz hipertrófica/terapia seguimentos administration topical

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