Comparative protection of mice against virulent and attenuated strains of Brucella abortus by passive transfer of immune T cells or serum.
AUTOR(ES)
Araya, L N
RESUMO
Passively transferred immune serum provided significantly greater protection to BALB/c mice against attenuated Brucella abortus 19 than against virulent strain 2308, whether serum donors had been infected with strain 19 or 2308. In contrast, immune T cells conferred better protection upon recipients challenged with the homologous strain of B. abortus. It is hypothesized that strain 2308, but not strain 19, can survive in macrophages after opsonization and that epitopes which induce protective cell-mediated immunity may differ between strains 19 and 2308.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=258438Documentos Relacionados
- Vaccination with Brucella abortus rough mutant RB51 protects BALB/c mice against virulent strains of Brucella abortus, Brucella melitensis, and Brucella ovis.
- Killing of Brucella abortus by bovine serum.
- Soluble antigens of virulent and attenuated biotypes of Brucella abortus.
- Survival of virulent and attenuated strains of Brucella abortus in normal and gamma interferon-activated murine peritoneal macrophages.
- Immunity to syphilis: passive transfer in rabbits using serial doses of immune serum.
