Comparison of basal cell carcinoma subtypes observed in preoperative biopsy and Mohs micrographic surgery,
AUTOR(ES)
Cerci, Felipe Bochnia; Kubo, Elisa Mayumi; Werner, Betina
FONTE
An. Bras. Dermatol.
DATA DE PUBLICAÇÃO
2020-10
RESUMO
Abstract Background: The treatment of basal cell carcinoma depends on its histological subtype. Therefore, a biopsy should be performed before definitive treatment. However, as the biopsy is only a sample of the tumor, it does not always shows every histological subtype present in the neoplasm. Few studies have compared the histological findings of biopsies with the findings of Mohs micrographic surgery. By evaluating the totality of the peripheral margins, in addition to sampling large tumor areas, this technique provides a more representative amount of tissue than preoperative biopsy. Objectives: a) Determine the agreement between the histological subtype of basal cell carcinoma from punch biopsy and the findings of Mohs surgery; b) To assess, among the discordant cases, the prevalence of non-aggressive tumors in the preoperative biopsy that were reclassified as aggressive by Mohs surgery. Methods: Retrospective analysis of 79 cases of basal cell carcinomas submitted to punch biopsy and subsequent Mohs surgery. Results: The agreement between the classification of the subtypes in the biopsy and in Mohs surgery was 40.5%. Punch biopsy was able to predict the most aggressive basal cell carcinoma growth pattern in 83% of cases. Study limitations: Retrospective nature, sample size, and biopsies performed by different professionals. Conclusions: The agreement between the histopathological subtypes of basal cell carcinoma as seen in preoperative biopsy and Mohs surgery was low. However, preoperative biopsy presented good accuracy (83%) in detecting aggressive histopathological subtypes.
Documentos Relacionados
- “DerMohscopy”: utility of dermoscopy combined with Mohs micrographic surgery for the treatment of basal cell carcinoma
- Keep it simple. A ten-year experience in reconstructions after Mohs micrographic surgery,
- The importance of superficial basal cell carcinoma in a retrospective study of 139 patients who underwent Mohs micrographic surgery in a Brazilian university hospital
- Penile squamous cell carcinoma: a review of the literature and case report treated with Mohs micrographic surgery
- Mohs' micrographic surgery of the head and neck.