Comparison of cilofungin and amphotericin B for therapy of murine candidiasis.
AUTOR(ES)
Smith, K R
RESUMO
We compared the efficacies of cilofungin and amphotericin B treatment in a murine model of disseminated candidiasis. Three different dosages of each drug plus controls were evaluated. Statistically improved survival was noted only among mice treated with 1 mg of amphotericin B per kg of body weight (P less than 0.05). While all amphotericin B regimens and the two lower-dosage cilofungin regimens significantly reduced yeast cell counts in kidneys compared with the controls, the amphotericin B-treated mice had a significantly higher percentage of sterile kidneys following therapy compared with those treated with cilofungin (P = 0.0001).
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=171887Documentos Relacionados
- Comparative effects of cilofungin and amphotericin B on experimental murine candidiasis.
- Synergy between cilofungin and amphotericin B in a murine model of candidiasis.
- Treatment of murine invasive candidiasis with amphotericin B and cilofungin: evidence for enhanced activity with combination therapy.
- Combination therapy of murine invasive candidiasis with fluconazole and amphotericin B.
- Saperconazole therapy of murine disseminated candidiasis: efficacy and interactions with amphotericin B.