Comparison of in vitro activities of eight beta-lactamase-stable cephalosporins against beta-lactamase-producing gram-negative bacilli.
AUTOR(ES)
Verbist, L
RESUMO
In vitro activities of eight beta-lactamase-stable cephalosporins, cefoxitin, cefuroxime, cefotaxime, moxalactam, SCE-1365, cefoperazone, ceftazidime, and cefsulodin, were compared against selected cephalothin-resistant or beta-lactamase-producing gram-negative bacilli or both. SCE-1365, cefotaxime, moxalactam, and ceftazidime had very similar activities against Enterobacteriaceae; SCE-1365 displayed the highest activity, and ceftazidime displayed the lowest activity. These four antibiotics were about 20 times more active than cefoperazone and 50 to 100 times more active than cefoxitin and cefuroxime. Against Pseudomonas aeruginosa and the other Pseudomonas species, ceftazidime showed the highest activity by far, followed by cefsulodin and cefoperazone. A close parallel resistance against P. aeruginosa isolates was observed between piperacillin on the one hand and cefoperazone and cefsulodin on the other.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=181446Documentos Relacionados
- Comparative activities of the beta-lactamase inhibitors YTR 830, clavulanate, and sulbactam combined with ampicillin and broad-spectrum penicillins against defined beta-lactamase-producing aerobic gram-negative bacilli.
- Activities of aztreonam and new cephalosporins against infrequently isolated gram-negative bacilli.
- Comparative in vitro activities of apalcillin and piperacillin against gram-negative bacilli.
- In vitro activities of moxalactam and cefotaxime against aerobic gram-negative bacilli.
- In vitro activities of quinolones, beta-lactams, tobramycin, and trimethoprim-sulfamethoxazole against nonfermentative gram-negative bacilli.