Comparison of In Vitro Activities of Ketolides, Macrolides, and an Azalide against the Spirochete Borrelia burgdorferi

AUTOR(ES)

Hunfeld, Klaus-Peter

FONTE

American Society for Microbiology

RESUMO

Two ketolides, three macrolides, and one azalide were tested in vitro against 17 isolates of the B. burgdorferi s.l. complex. As measured in micrograms per milliliter, activity was highest for cethromycin (MIC at which 90% of the tested isolates were inhibited [MIC90], 0.0019 μg/ml) and telithromycin (MIC90, 0.0078 μg/ml). Electron-microscope analysis and time-kill studies also supported enhanced effectiveness of both ketolides.

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