Comparison of major protein antigens and protein profiles of Treponema pallidum and Treponema pertenue.
AUTOR(ES)
Thornburg, R W
RESUMO
The protein profiles of Treponema pallidum and Treponema pertenue, the causative agents of syphilis and yaws, respectively, were compared by one- and two-dimensional gel electrophoresis. One-dimensional gels showed essentially no differences in the protein patterns of these treponemes. On two-dimensional gels most radiolabeled protein species were shared; however, variations were noticed in several minor protein species. Antigenic comparison by radioimmunoprecipitation and Western blotting also demonstrated similarities between these spirochetes. However, lactoperoxidase-catalyzed iodination of T. pallidum and T. pertenue suggested differences in their surface proteins.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=264474Documentos Relacionados
- Molecular basis of immunological cross-reactivity between Treponema pallidum and Treponema pertenue.
- Use of CB hamsters in the study of Treponema pertenue.
- Genetic relationship between Treponema pallidum and Treponema pertenue, two noncultivable human pathogens.
- Treponema pallidum subsp. pertenue Displays Pathogenic Properties Different from Those of T. pallidum subsp. pallidum
- Ability of enriched immune T cells to confer resistance in hamsters to infection with Treponema pertenue.