Comparison of maxicircle DNAs of Leishmania tarentolae and Trypanosoma brucei.

AUTOR(ES)

Muhich, M L

RESUMO

The conserved portions of the maxicircle DNAs of Leishmania tarentolae and Trypanosoma brucei are organized in a basically colinear manner over a 15- to 17-kilobase region that is interrupted by two small less-homologous sequences. The most highly conserved regions are those encoding the 9S and 12S genes. An approximately 12-kilobase region directly upstream of the 12S gene in the L. tarentolae maxicircle showed no sequence homology with the T. brucei maxicircle and also was not transcribed. An approximately 6-kilobase region in the T. brucei maxicircle in the same relative location also showed no sequence homology with the L. tarentolae maxicircle. We propose that evolution of maxicircle DNA occurs mainly within this "divergent region."

Documentos Relacionados

• Kinetoplast maxicircle DNA replication in Crithidia fasciculata and Trypanosoma brucei.
• Localization of kinetoplast DNA maxicircle transcripts in bloodstream and procyclic form Trypanosoma brucei.
• Mapping and 5' end determination of kinetoplast maxicircle gene transcripts from Leishmania tarentolae.
• Indomethacin promotes differentiation of Trypanosoma brucei.
• RNA turnover in Trypanosoma brucei.