Comparison of the Yields of Blood Cultures Using Serum or Plasma from Patients with Early Lyme Disease

AUTOR(ES)

Wormser, Gary P.

FONTE

American Society for Microbiology

RESUMO

In an initial experiment, culture-grown Borrelia burgdorferi was added to freshly collected uninfected human blood. This in vitro study demonstrated that more spirochetes were distributed into the plasma than into the serum fraction. In a subsequent clinical study, B. burgdorferi was recovered from plasma cultures of approximately 50% of 42 patients with early Lyme disease associated with erythema migrans. The rate of recovery from plasma cultures was significantly greater than that from serum cultures (P < 0.001).

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