COMPLEMENT COMPONENTS REQUIRED FOR VIRUS NEUTRALIZATION BY EARLY IMMUNOGLOBULIN ANTIBODY*
AUTOR(ES)
Linscott, William D.
RESUMO
Virus neutralization by early antisera usually requires or is enhanced by the presence of complement. The particular components of the complement system which are needed for neutralization of Newcastle disease virus by early IgM antibodies were studied. It was found in this system that participation of only the first four of the nine complement components (C1, C2, C3, and C4) was necessary and sufficient for neutralization to occur. It was concluded that the role of complement in neutralization was most likely that of contributing bulk in the form of large protein molecules to the virus-antibody complex.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=223375Documentos Relacionados
- Neutralization of Sensitized Virus by Purified Components of Complement*†
- Early complement components enhance neutralization of Chlamydia trachomatis infectivity by human sera.
- Complement requirement for virus neutralization by antibody and reduced serum complement levels associated with experimental equine herpesvirus 1 infection.
- Mouse immunoglobulin antibodies require complement for neutralization of mouse retroviruses.
- Complement-Mediated Enhancement of Antibody Function for Neutralization of Pseudotype Virus Containing Hepatitis C Virus E2 Chimeric Glycoprotein