Complementation analysis of resistance to 5-fluorocytosine in Candida albicans.
AUTOR(ES)
Whelan, W L
RESUMO
A complementation test was devised to study allelism among the genetic determinants of resistance to 5-fluorocytosine in Candida albicans. Complementation was demonstrated in control hybrids produced by crossing a resistant strain that was deficient in cytosine deaminase activity with four other resistant strains deficient in UMP pyrophosphorylase activity. This complementation test was used to test allelism of the resistance determinants present in five clinical isolates. All were found to bear recessive alleles of the locus (FCY1) that determined 5-fluorocytosine resistance associated with low levels of UMP pyrophosphorylase activity.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=284142Documentos Relacionados
- Decreased activity of UMP pyrophosphorylase associated with resistance to 5-fluorocytosine in Candida albicans.
- In Vitro Studies of 5-Fluorocytosine Resistance in Candida albicans and Torulopsis glabrata
- Experimental endocarditis: prophylaxis of Candida albicans infections by 5-fluorocytosine in rabbits.
- Chemotherapeutic Activity of 5-Fluorocytosine Against a Lethal Candida albicans Infection in Mice
- Chemotherapeutic Activity of 5-Fluorocytosine and Amphotericin B Against Candida albicans in Mice