Complete, 12-subunit RNA polymerase II at 4.1-Å resolution: Implications for the initiation of transcription
AUTOR(ES)
Bushnell, David A.
FONTE
National Academy of Sciences
RESUMO
The x-ray structure of complete RNA polymerase II from Saccharomyces cerevisiae has been determined, including a heterodimer of subunits Rpb4 and Rpb7 not present in previous “core” polymerase II structures. The heterodimer maintains the polymerase in the conformation of a transcribing complex, may bind RNA as it emerges from the enzyme, and is in a position to interact with general transcription factors and the Mediator of transcriptional regulation.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=165814Documentos Relacionados
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