Complete nucleotide sequence of an infectious clone of human T-cell leukemia virus type II: an open reading frame for the protease gene.
AUTOR(ES)
Shimotohno, K
RESUMO
The entire nucleotide sequence of an infectious clone of human T-cell leukemia virus type II provirus was determined. This provirus consists of 8952 nucleotides. In addition to long terminal repeats and gag, pol, env, and X, a protease gene that is responsible for processing the gag precursor protein was found. The protease gene is encoded in a different frame from gag and pol and was located between the gag and pol open reading frames. The 5' region of the protease gene overlaps the 3' gag region. Coding regions of the provirus show about 60% homology with those of human T-cell leukemia virus type I at the nucleotide level. The evolutionary relationship between human T-cell leukemia virus types I and II is discussed.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=397722Documentos Relacionados
- Nucleotide sequence of the 3' region of an infectious human T-cell leukemia virus type II genome.
- Characterization of an infectious molecular clone of human T-cell leukemia virus type I.
- Nucleotide sequence analysis of the long terminal repeat of human T-cell leukemia virus type II.
- Human adult T-cell leukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA.
- Rex transregulation of human T-cell leukemia virus type II gene expression.