Concanavalin A inhibits tissue factor coagulant activity.
AUTOR(ES)
Pitlick, F A
RESUMO
Concanavalin A (con A) is a potent inhibitor of coagulant activity of native tissue factor. Coagulant activity is recovered by addition of alpha-methyl-D-glucoside to inhibited tissue factor. Inclusion of alpha-methyl-D-glucose during incubation of con A with tissue factor preserves coagulant activity. These data suggest that con A interacts reversibly with a carbohydrate residue in such a way as to inhibit coagulant activity of the molecule. Purified tissue factor apoprotein has been recombined with mixed brain phospholipids or purified phospholipids (phosphatidyl ethanolamine or a mixture of phosphatidyl choline with phosphatidyl serine). These preparations were also completely but reversibly inhibited by con A. Thus, purified tissue factor apoprotein appears to donate the affected carbohydrate residue.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=301729Documentos Relacionados
- Coagulant Activity of Leukocytes. TISSUE FACTOR ACTIVITY
- Development and validation of an assay for urinary tissue factor activity.
- Reverse transcriptase inhibits Taq polymerase activity.
- Tissue factor activity. A marker of alveolar macrophage maturation in rabbits. Effects of granulomatous pneumonitis.
- Differentiation of immortal cells inhibits telomerase activity.
