Congophilic angiopathy of the brain: a clinical and pathological report on two siblings.
AUTOR(ES)
Griffiths, R A
RESUMO
Clinical and histological accounts are given of a sister and brother, dying aged 61 and 56 years respectively after illnesses lasting 5-6 years marked by a progressive mental and physical disability. The family history suggested transmission by a dominant gene. The histological findings were of a very severe congophilic angiopathy confined to the brain, spinal cord and leptomeninges and giving rise to multiple haemorrhages and softenings. There were, in addition, abundant amyloid-containing "plaques" of various forms, found principally in the hippocampus and cerebellar cortex. The cases are compared with similar cases in the literature, and reasons given for regarding this condition as a separate entity rather than a variant of Alzheimer's disease.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1083118Documentos Relacionados
- Angioma Arteriale Racemosum in an Acallosal Brain: A Clinical and Pathological Report
- Congenital muscular dystrophy with severe retrocollis and mental retardation: a report of two siblings.
- Congenital ophthalmoplegia. A myopathic aetiology in two siblings.
- Chronic inflammatory demyelinating polyneuropathy in two siblings.
- IgM monoclonal gammopathy and neuropathy in two siblings.