Contribution of CD8+ T Cells to Gamma Interferon Production in Human Tuberculosis
AUTOR(ES)
Shams, Homayoun
FONTE
American Society for Microbiology
RESUMO
The proportions of peripheral blood mononuclear cells (PBMC), CD4+ T cells, and CD8+ T cells that produce gamma interferon (IFN-γ) in response to Mycobacterium tuberculosis were markedly reduced in tuberculosis patients, particularly in those with severe disease. Depletion of CD4+ but not CD8+ cells prior to stimulation of PBMC with M. tuberculosis abolished IFN-γ production. These results show that (i) IFN-γ production by CD8+ and CD4+ cells correlates with the clinical manifestations of M. tuberculosis infection and (ii) IFN-γ production by CD8+ cells depends on CD4+ cells.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=98319Documentos Relacionados
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