Control of Sindbis Virus Infection by Antibody in Interferon-Deficient Mice

AUTOR(ES)

Byrnes, Andrew P.

FONTE

American Society for Microbiology

RESUMO

Antibodies clear Sindbis virus from infected animals through an unknown mechanism. To determine whether interferon-induced pathways are required for this clearance, we examined mice which are unable to respond to alpha/beta interferon or gamma interferon. Although extremely susceptible to infection, such mice survived and completely cleared virus if antibodies against Sindbis virus were given.

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