Cooperative binding of EF-1A to the E1A enhancer region mediates synergistic effects on E1A transcription during adenovirus infection.
AUTOR(ES)
Bruder, J T
RESUMO
A cellular nuclear factor, EF-1A, binds to a sequence motif which is repeated in the adenovirus type 5 E1A transcriptional control region. Previous genetic analyses demonstrated that two of these binding sites are predominant functional elements of the E1A enhancer region in vivo. In this report, we demonstrate that the cooperative binding of EF-1A to neighboring sites in the E1A enhancer region results in a synergistic activation of E1A transcription in infected cells.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=248974Documentos Relacionados
- Nuclear factor EF-1A binds to the adenovirus E1A core enhancer element and to other transcriptional control regions.
- Interaction of nuclear factor EF-1A with the polyomavirus enhancer region.
- Mutations in the adenovirus major late promoter: effects on viability and transcription during infection.
- Adenovirus E1A protein activates transcription of the E1A gene subsequent to transcription complex formation.
- Differential effects of the adenovirus E1A oncogene on members of the AP-1 transcription factor family.