Coordinate regulation of the synthesis of eukaryotic ribosomal proteins.
AUTOR(ES)
Gorenstein, C
RESUMO
We have developed a method of r the direct measurement, in eukaryotic cells, of the synthesis of ribosomal proteins, irrespective of the synthesis of ribosomes. In this way the synthesis of ribosomal proteins has been examined in mutant strains of Saccharomyces cerevisiae, which are unable to synthesize ribosomes under nonpermissive conditions. The results suggest that the synthesis of more than 40 ribosomal proteins is under coordinate control. Under nonpermissive conditions,the synthesis of each h protein declines exponentially to a basal level which is 10-20% fo normal. The kinetics of that decline suggest that an early, if not primary, result of the nonpermissive conditions is the cessation of production of new mRNA for eac of the ribosomal proteins. The coordinate regulation appears not to be influenced directly by the rate of transcription of ribosomal precursor RNA.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=430334Documentos Relacionados
- Coordinate regulation of downstream genes by extradenticle and the homeotic selector proteins.
- Regulation of mitochondrial protein synthesis by cytoplasmic proteins.
- Predicting the orientation of eukaryotic membrane-spanning proteins.
- Selective effects of inhibitors of protein synthesis on metabolism of nuclear anc cytoplasmic proteins: evidence for coordinate synthesis of non-histone chromosomal proteins.
- Coordinate translational regulation in the syntheses of elongation factor 1 alpha and ribosomal proteins in Xenopus laevis.