Correlation of the physical and genetic maps in the lin-12 region of Caenorhabditis elegans.
AUTOR(ES)
Greenwald, I
RESUMO
We describe the assembly of a set of overlapping clones from the lin-12 III chromosomal region that spans approximately 600 kb, and the identification of two restriction fragment length polymorphisms, eP6 and eP7, that flank the lin-12 locus. A comparison of the physical map and the genetic map yields approximate measurements of 930 kb/map unit for the eP6--lin-12 interval and 830 kb/map unit for the lin-12--eP7 interval. We interpret these values as supporting the proposal that the apparent clustering of genes observed for C. elegans autosomes results from decreased recombination frequency in clusters and not from nonrandom distribution of genes on the physical map.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=340635Documentos Relacionados
- Genetic and Phenotypic Studies of Hypomorphic Lin-12 Mutants in Caenorhabditis Elegans
- Suppressors of a Lin-12 Hypomorph Define Genes That Interact with Both Lin-12 and Glp-1 in Caenorhabditis Elegans
- Functional domains of LAG-2, a putative signaling ligand for LIN-12 and GLP-1 receptors in Caenorhabditis elegans.
- Identification and Characterization of Genes That Interact with Lin-12 in Caenorhabditis Elegans
- SEL-8, a nuclear protein required for LIN-12 and GLP-1 signaling in Caenorhabditis elegans