CpG content affects gene silencing in mice: evidence from novel transgenes
AUTOR(ES)
Chevalier-Mariette, Christine
FONTE
BioMed Central
RESUMO
It has been demonstrated that the density of CpG sequences in the transcribed regions of transgenes can have a causal role in repression of transcription. These results show that the mechanism by which CpG islands escape de novo methylation is sensitive to CpG density of adjacent sequences.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=193653Documentos Relacionados
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