Critical roles of TRAIL in hepatic cell death and hepatic inflammation
AUTOR(ES)
Zheng, Shi-Jun
FONTE
American Society for Clinical Investigation
RESUMO
The TNF-related apoptosis-inducing ligand (TRAIL) induces apoptosis of tumor cells but not most normal cells. Its role in hepatic cell death and hepatic diseases is not clear. In vitro studies suggest that murine hepatocytes are not sensitive to TRAIL-induced apoptosis, indicating that TRAIL may not mediate hepatic cell death. Using two experimental models of hepatitis, we found that hepatic cell death in vivo was dramatically reduced in TRAIL-deficient mice and mice treated with a blocking TRAIL receptor. Although both TRAIL and its death receptor 5 were constitutively expressed in the liver, TRAIL expression by immune cells alone was sufficient to restore the sensitivity of TRAIL-deficient mice to hepatitis. Thus, TRAIL plays a crucial role in hepatic cell death and hepatic inflammation.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=300768Documentos Relacionados
- Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation
- μ‐Opioid receptor activation prevents acute hepatic inflammation and cell death
- Critical roles of PPARβ/δ in keratinocyte response to inflammation
- Astrovirus Induces Diarrhea in the Absence of Inflammation and Cell Death
- Critical Roles for stx2, eae, and tir in Enterohemorrhagic Escherichia coli-Induced Diarrhea and Intestinal Inflammation in Infant Rabbits