Cross-reacting herpes simplex virus antigens in hamster and mouse cells transformed by ultraviolet light-inactivated herpes simplex virus type 2.
AUTOR(ES)
Boyd, A L
RESUMO
Murine and hamster cell lines, each transformed with a different strain of herpes simplex virus (HSV), were examined for cross-reacting antigens by in vitro and in vivo assays. A comparative study by the indirect immunofluorescence technique detected common cross-reacting viral antigens. Cytoplasmic fluorescence patterns were observed in the 333-8-9 hamster line, the H238 murine line, and the H238 clonal lines; these patterns were identical to the fluorescence pattern of HSV -2-infected controls when reacted with HSV antiserum. Tumor rejection studies in the BALB/c host indicated that each cell line provided immunity against a tumorigenic challenge of transformed mouse cells. The H238 clone EC1 3 provided a 53% immunity against itself at an inoculum of 10(6); the 333-8-9 line supported a 26% immunity. These data demonstrate a common HSV antigenicity between the murine and hamster transformed lines and further indicate that the HSV genome is involved in transformation.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=420692Documentos Relacionados
- Analysis of viral DNA sequences in hamster cells transformed by herpes simplex virus type 2.
- Neutralization of Epstein-Barr Virus by Nonimmune Human Serum: ROLE OF CROSS-REACTING ANTIBODY TO HERPES SIMPLEX VIRUS AND COMPLEMENT
- Cross-reacting lipopolysaccharide antigens in Legionella pneumophila serogroups 1 to 14.
- Absence of Leukosis Virus Markers in Hamster Cells Transformed by Herpes Simplex Virus Type 2
- Quantitation of serotype-specific and cross-reacting group-specific antigens by coagglutination and immunodiffusion tests for differentiating Actinobacillus (Haemophilus) pleuropneumoniae strains belonging to cross-reacting serotypes 3, 6, and 8.
