Cross-Reactivity of HLA-B*1801-Restricted T-Lymphocyte Clones with Target Cells Expressing Variants of the Human Cytomegalovirus 72kDa-IE1 Protein
AUTOR(ES)
Prod'homme, Virginie
FONTE
American Society for Microbiology
RESUMO
The impact of natural polymorphism in a cytomegalovirus-dominant HLA-B*1801-restricted epitope, IE1199-206, on the specific responses of T-cell clones was assessed by measuring their cytolytic activity against target cells expressing mutated recombinant IE1 proteins. Our results suggest an in vivo selection of T lymphocytes that cross-react with multiple IE1 variants.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=156178Documentos Relacionados
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