Cryptic signals and the fidelity of V(D)J joining.
AUTOR(ES)
Lewis, S M
RESUMO
V(D)J recombination is responsible for the de novo creation of antigen receptor genes in T- and B-cell precursors. To the extent that lymphopoiesis takes place throughout an animal's lifetime, recombination errors present an ongoing problem. One type of aberrant rearrangement ensues when DNA sequences resembling a V(D)J joining signal are targeted by mistake. This study investigates the type of sequence likely to be subject to mistargeting, the level of joining-signal function associated with these sequences, and the number of such cryptic joining signals in the genome.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=232165Documentos Relacionados
- Cutting and closing without recombination in V(D)J joining.
- Nonhomologous end joining and V(D)J recombination require an additional factor
- A V(D)J recombinase-inducible B-cell line: role of transcriptional enhancer elements in directing V(D)J recombination.
- Targeted Transposition by the V(D)J Recombinase
- Fine Structure and Activity of Discrete RAG-HMG Complexes on V(D)J Recombination Signals