Cryptosporidium parvum infection in T-cell receptor (TCR)-alpha- and TCR-delta-deficient mice.
AUTOR(ES)
Waters, W R
RESUMO
Mice deficient in either alpha beta or gamma delta T cells were more susceptible to infection with the protozoan parasite Cryptosporidium parvum than were control mice. Both neonatal and adult alpha beta-T-cell-deficient mice developed chronic infection. Gamma delta-T-cell-deficient neonatal mice were more susceptible than control mice but were able to clear the infection. Adult gamma delta-T-cell-deficient mice were not susceptible to infection. These data indicate that alpha beta T cells are important for resistance to C. parvum while gamma delta T cells have a less critical role.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=174004Documentos Relacionados
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