Cyclic AMP and Sodium Transport: QUANTITATIVE AND TEMPORAL RELATIONSHIPS IN TOAD URINARY BLADDER
AUTOR(ES)
Sapirstein, Victor S.
RESUMO
The effects of oxytocin upon tissue cAMP content and short-circuit current (SCC) were measured in the urinary bladder of the toad, Bufo marinus. Tissue cAMP levels doubled before any increment in SCC was observed, the two hormone responses were quantitatively related, and a threshold level for an effect of cAMP upon sodium transport was demonstrated. The period of time over which cAMP levels continued to rise after the threshold level had been attained seemed invariant with hormone concentration. The rate at which cAMP levels rose increased with hormone concentration yielding hormone concentration-dependent maximal levels. The decay of cAMP levels was delayed when sodium influx was curtailed, suggesting a sodium-regulatory effect upon tissue cAMP levels.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=333042Documentos Relacionados
- Energetics of sodium transport in toad urinary bladder.
- Energetics of sodium transport in the urinary bladder of the toad. Effect of aldosterone and sodium cyanide.
- Effects of hormonal and electrical stimulation of sodium transport on metabolism of toad urinary bladder.
- Toad urinary bladder epithelial cells in culture: maintenance of epithelial structure, sodium transport, and response to hormones.
- Intracellular sodium ion activity and sodium transport in rabbit urinary bladder.