Cyclosporin A prevents induction of the interleukin 2 receptor gene in cultured murine thymocytes.
AUTOR(ES)
Gauchat, J F
RESUMO
Blast formation and mitotic activation of G0-arrested mouse thymocytes were triggered by the addition of concanavalin A plus interleukin 2 (IL-2) to the culture medium. When added alone, Con A induces within 6 hr a complex reprogramming ("priming") that comprises the activation of the IL-2 receptor gene. The primed thymocytes are competent to interact with IL-2 and to respond to its growth-promoting effect, which corresponds to blast formation and mitotic activation. Cyclosporin A, an immunosuppressive cyclic peptide of fungal origin, prevents in T lymphocytes the activation of a set(s) of genes encoding lymphokines and the IL-2 receptor but does not affect their expression once they have been activated. The biomedical implications of these observations are discussed.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=386517Documentos Relacionados
- Activation of phosphatidylinositol-3 kinase by ligation of the interleukin-7 receptor on human thymocytes.
- Interleukin 2 promotes growth and cytolytic activity in human T3+4-8- thymocytes.
- Phosphorylation at a tyrosine residue of lipomodulin in mitogen-stimulated murine thymocytes.
- Abnormal deletions in the T-cell receptor delta locus of mouse thymocytes.
- Regulation of RAG-2 protein expression in avian thymocytes.
