Cytotoxic analogs of the iron(III) chelator pyridoxal isonicotinoyl hydrazone: effects of complexation with copper(II), gallium(III), and iron (III) on their antiproliferative activities.
AUTOR(ES)
Richardson, D R
RESUMO
This study examined if complexation with metals increased the antiproliferative activities of chelators of the pyridoxal isonicotinoyl hydrazone (PIH) class. Addition of iron(III) to some PIH analogs markedly depressed their activities, whereas it had little effect on others. The gallium(III) complex of PIH, but not its copper(II) complex, was more efficient than the apochelator at inhibiting [3H]thymidine incorporation.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=164070Documentos Relacionados
- Spectroscopic investigations of iron(II) and iron(III) oxalates
- Ferrioxamine-Mediated Iron(III) Utilization by Salmonella enterica
- Mechanistically novel iron(III) transport system in Serratia marcescens.
- Localization and Solubilization of the Iron(III) Reductase of Geobacter sulfurreducens
- Iron(III) chloride catalyzed glycosylation of peracylated sugars with allyl/alkynyl alcohols