Defective Epidermal Barrier in Neonatal Mice Lacking the C-Terminal Region of Connexin43D⃞V⃞
AUTOR(ES)
Maass, Karen
FONTE
The American Society for Cell Biology
RESUMO
More than 97% of mice in which the C-terminal region of connexin43 (Cx43) was removed (designated as Cx43K258stop) die shortly after birth due to a defect of the epidermal barrier. The abnormal expression of Cx43K258stop protein in the uppermost layers of the epidermis seems to perturb terminal differentiation of keratinocytes. In contrast to Cx43-deficient mice, neonatal Cx43K258stop hearts show no lethal obstruction of the right ventricular outflow tract, but signs of dilatation. Electrocardiographies of neonatal hearts reveal repolarization abnormalities in 20% of homozygous Cx43K258stop animals. The very rare adult Cx43K258stop mice show a compensation of the epidermal barrier defect but persisting impairment of cardiac function in echocardiography. Female Cx43K258stop mice are infertile due to impaired folliculogenesis. Our results indicate that the C-terminally truncated Cx43K258stop mice lack essential functions of Cx43, although the truncated Cx43 protein can form open gap junctional channels.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=519152Documentos Relacionados
- An Abf1p C-terminal region lacking transcriptional activation potential stimulates a yeast origin of replication.
- The Role of Hemoglobin's C-terminal Region: the Work of Eraldo Antonini
- The C-terminal region of the Escherichia coli UvrC protein, which is homologous to the C-terminal region of the human ERCC1 protein, is involved in DNA binding and 5'-incision.
- Phosphorylation of KSP motifs in the C-terminal region of titin in differentiating myoblasts.
- The C-terminal region of human angiogenin has a dual role in enzymatic activity.