Demonstration of an abnormality of C apoprotein of very low density lipoprotein in patients with gout.
AUTOR(ES)
Macfarlane, D G
RESUMO
The very low density (VLDL) apolipoproteins of 12 male patients with gout have been studied by analytical isoelectric focusing. The relative percentage distribution of the C apolipoproteins was calculated and compared with that from 12 normolipidaemic and 12 'lipid-matched' controls. In the gout patients apolipoprotein CII (apo CII) represented 19.6% of the VLDL C proteins and the CII/CIII2 ratio was 0.57. In the normolipidaemic controls apo CII represented 28.8% and in the lipid-matched controls 33.1% of VLDL apo C, and the CII/CIII2 ratio approached one in each control group. These differences were significant. This suggests that a reduction in VLDL apo CII may predispose to the hypertriglyceridaemia that is commonly found in patients with gout.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1001658Documentos Relacionados
- The Interaction of Heparin with an Apoprotein of Human Very Low Density Lipoprotein
- Catabolism of Very Low Density Lipoprotein B Apoprotein in Man
- Increased concentrations of serum Lp(a) lipoprotein in patients with primary gout.
- Evidence for the identity of the major apoprotein in low density and very low density lipoproteins in normal subjects and patients with familial hyperlipoproteinemia
- Withdrawal of allopurinol in patients with gout.